Synthetic Methodology and Catalysis Laboratory

PUBLICATIONS
Lin, A.; Lee, S; Knowles, R. R.
Acc. Chem. Res. 2024, 57, 1827. https://doi.org/10.1021/acs.accounts.4c00227
Prior publications
9. Modular Synthesis of Unnatural Peptides via Rh(III)-Catalyzed Diastereoselective Three-Component Carboamidation Reaction
Lamartina, C.; Cassandra, C.; Lee, S.; Shah, N.; Rovis, T.
J. Am. Chem. Soc. 2023, 145, 1129. https://doi.org/10.1021/jacs.2c10793
8. Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19.
Liu, H.; Iketani, S.; Zask, A.; Khanizeman, N.; Bednarova, E.; Forouhar, F.; Fowler, B.; Hong, S. J.; Mohri, H.; Nair, M. S.; Huang, Y.; Tay, N. E. S.; Lee, S.; Karan, C.; Resnick, S. J.; Quinn, C.; Li, W.; Shion, H.; Xia, X.; Daniels, J. D.; Bartolo-Cruz, M.; Farina, M.; Rajbhandari, P.; Jurtschenko, C. Lauber, M. A.; McDonald, T.; Stokes, M. E.; Hurst, B. L.; Rovis, T.; Chavez, A.; Ho, D. D.; Stockwell, B. R.
Nat. Commun. 2022, 13, 1891. https://doi.org/10.1038/s41467-022-29413-2
7.Rh(III)-Catalyzed Three-Component Syn-Carboamination of Alkenes Using Arylboronic Acids and Dioxazolones.
Lee, S.; Rovis, T.
ACS Catal. 2021, 11, 8585. https://doi.org/10.1021/acscatal.1c02406
6. Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity.
Resnick, S. J.; Iketani, S.; Hong, S. J.; Zask, A.; Liu, H.; Kim, S.; Melore, S.; Lin, F. Y.; Nair, M. S.; Huang, Y.; Lee, S.; Tay, N. E. S.; Rovis, T.; Yang, H. W.; Xing, Li.; Stockwell, B. R.; Ho, D. D.; Chavez, A.
J Virol. 2021, 95, 1. https://doi.org/10.1128/jvi.02374-20
5. Direct Regio- and Diastereoselective Synthesis of d-Lactams from Acrylamides and Unactivated Alkenes Initiated by Rh(III)-catalyzed C-H Activation.
Lee, S.; Semakul, N.; Rovis, T.
Angew. Chem. Int. Ed. 2020, 59, 4965. https://doi.org/10.1002/anie.201916332
4. Rhodium(III)-Catalyzed Three-Component 1,2-Diamination of Unactivated Terminal Alkenes.
Lee, S.; Jang, Y. J.; Phipps, E. J. T.; Lei, H.; Rovis, T.
Synthesis. 2020, 52, 1247. http://doi.org/10.1055/s-0039-1690756
3. A Rh(III)-Catalyzed Formal [4+1] Approach to Pyrrolidines from Unactivated Terminal Alkenes and Nitrene Sources
Lee, S.; Lei, H.; Rovis, T.
J. Am. Chem. Soc. 2019, 141, 12536. https://doi.org/10.1021/jacs.9b07012
2. Fluorescent turn-on Zn2+ sensing in aqueous and cellular media.
Lee, S.; Lee, J. H.; Pradhan, T.; Lim, C. S.; Cho, B. R.; Bhuniya, S.; Kim, J. S.
Sensors and actuators B: Chemical 2011, 160, 1489. https://doi.org/10.1016/j.snb.2011.07.065
1. Uridine-based paramagnetic supramolecular nanoaggregate with high relaxivity capable of detecting primitive liver tumor lesions.
Bhuniya, S.; Moon, H.; Lee, H.; Hong, K. S.; Lee, S.; Kim, J. S.
Biomaterials, 2011, 32, 6533. https://doi.org/10.1016/j.biomaterials.2011.05.054